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Born in Houston but raised in Charleston, Garner showed an early passion for dance and theater during her childhood. Her breakthrough TV role was Sydney Bristow in the series Alias (2001-2006), earning Garner a Golden Globe. Her film roles include Catch Me If You Can (2002), Daredevil (2003), Juno (2007), and Dallas Buyers Club (2013). Garner also works in the theater, including starring in the Broadway production of Cyrano de Bergerac with Kevin Kline in 2007.
Garner is a committed philanthropist, serving as an ambassador for Save the Children. She also co-founded Once Upon a Farm, which creates fresh baby food with a focus on health and sustainability.